| Research Publications |
| Postdoctoral-Research Work Publications |
| [1] |
Cabodevilla AG, Calistru C, Younis W, Nasias D, Ho TW, Anaganti N, Valmiki S, Rajan S, Gjini J, Kore R, Hannemann C. The N-terminus of Apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells. The Journal of Clinical Investigation. 2026 Apr 23. |
| [2] |
Younis W, Cui C, Sadeghian T, Burboa P, Shu P, Qin Y, Xie LH, Gallardo ML, Beuve A. Soluble guanylyl cyclase, the NO-receptor, regulates endothelium-dependent vascular relaxation via its transnitrosation activity. PNAS, 2025. |
| [3] |
Ainara G. Cabodevilla, Debapriya Basu, Waqas Younis, Munichandra Babu Tirumalasetty, Qing Robert Miao, Dimitris Nasias, Jenny E. Kanter, Winnie Ho, Jana Gjini, Edward A. Fisher, Jeffrey Kim, Warren Lee, Karin E. Bornfeldt, Ira J. Goldberg: Non-remnant triglyceride-rich lipoproteins due to lipoprotein lipase deficiency increase atherosclerosis: Nature communications, 2025. |
| [4] |
Cui C, Shu P, Sadeghian T, Younis W, Li H, Beuve A. Inhibitory Peptide of Soluble Guanylyl Cyclase/Trx1 Interface Blunts the Dual Redox Signaling Functions of the Complex. Antioxidants. 2023, 10;12(4):906. |
| [5] |
Goldberg IJ, Cabodevilla AG, Younis W. In the Beginning, Lipoproteins Cross the Endothelial Barrier. Journal of Atherosclerosis and Thrombosis. 2024 Jun 1;31(6):854-60. |
| [6] |
Younis W, Goldberg IJ. Can another lipid, sphingosine-1-phosphate, treat atherosclerosis?. Cardiovascular Research. 2024 Apr;120(5):435-6. |
| [7] |
Son NH, Son S, Verano M, Liu ZX, Younis W, Komack M, Ruggles KV, Gjini J, Tang ST, Cabodevilla AG, Liang FX. Cardiac lipid droplets differ under pathological and physiological conditions. Journal of Lipid Research. 2025 Oct 1:100920. |
| PHD-Research Work First Author Publications |
| [8] |
Younis W, Schini-Kerth VB, Junior AG, Majid M. Cardioprotective effect of Asphodelus tenuifolius Cav. on blood pressure and metabolic alterations in glucose-induced metabolic syndrome rats–An ethnopharmacological approach. Journal of Ethnopharmacology. 2018, 25;214:168-78. |
| [9] |
Younis W, Schini-Kerth VB, da Silva DB, Junior AG, Bukhari IA, Assiri AM. Role of the NO/cGMP pathway and renin-angiotensin system in the hypotensive and diuretic effects of aqueous soluble fraction from Crataegus songarica K. Koch. Journal of ethnopharmacology. 2020, 1;249:112400. |
| [10] |
Younis W, Schini-Kerth VB, Farooq MA, Althobaiti M, Roberts RE. Hawthorn berry (crataegus songarica) causes endothelium-dependent relaxation of the porcine coronary artery: Role of Estrogen receptors. Journal of Berry Research. 2021, 1;11(2):249-65. |
| [11] |
Younis W, Schini-Kerth VB, Nocchi SR, Silva DB, de Souza P, Bukhari IA, Vohra F, Afzal S, Gasparotto Junior A. Involvement of Muscarinic Receptors in Hypotensive and Diuretic Effects of Aqueous Soluble Fraction from Asphodelus tenuifolius Cav. Evidence-Based Complementary and Alternative Medicine. 2021, 15;2021. |
| [12] |
Younis W, Schini-Kerth VB, Junior AG, Nocchi SR, Silva DB, Roberts RE. Endothelium-independent vasorelaxant effect of Asphodelus tenuifolius Cav. via inhibition of myosin light chain kinase activity in the porcine coronary artery. Journal of Ethnopharmacology. 2021, 6;269:113693. |
| [13] |
Younis W, Alamgeer A, Malik MN, Alsahli TG, Manzoor W, Majid M, Imran MZ, Razzaq MA, Garcia AA, Lourenço EL, Marques AA. Crataegus songarica Fruit Ameliorates Oxidative Stress, Hypertension, and Endothelial Dysfunction in Glucose-Induced Hypertensive Rats. Journal of Medicinal Food. 2025 Jul 9. |
| Corresponding/Senior Author Publications |
| [14] |
Ehsan R, Pessoa LB, Younis W, Manzoor W, Malik MN, Mushtaq MN, Alsahli TG, Razzaq MA, dos Reis Lívero FA, Junior AG. The potential of volatile oil farnesol as a new treatment for hypertension and improvement of vascular function in hypertensive rats. Journal of Future Foods. 2025 Jul 3. |
| [15] |
Munir S, Hafeez R, Younis W, Malik MN, Munir MU, Manzoor W, Razzaq MA, Pessoa LB, Lopes KS, Lívero FA, Gasparotto Junior A. The protective effect of citronellol against doxorubicin-induced cardiotoxicity in rats. Biomedicines. 2023 Oct 18;11(10):2820. |
| [16] |
Shabeer A, Manzoor W, Younis W, Uttra AM, Alamgeer, Mushtaq N, Lateef M, Hasan UH, Nasim MB, Hassan MZ, Uddin J. Assessment of anti-arthritic potential of pulegone in formaldehyde-and Complete Freund’s Adjuvant-induced arthritis in rats. Inflammopharmacology. 2025 Jul;33(7):3983-99. |
| [17] |
Aslam S, Younis W, Malik MN, Jahan S, Uttra AM, Munir MU, Roman M. Pharmacological evaluation of anti- arthritic potential of terpinen-4-ol using in vitro and in vivo assays. Inflammopharmacology. 2022, 30(3):945-59. |
| [18] |
NAWAZ SS, Younis W, Gaspratto JA, Manzoor W, Malik MN, Mushtaq MN, Munir MU, Bashir A, BIBI S, Talha M, LIVERO F. Diuretic and anti-hyperuricemic effects of geranyl acetate in rats. Current medicinal chemistry. 2024;31. |
| [19] |
Razzaq MA, Younis W, Malik MN, Alsahli TG, Jahan S, Ehsan R, Gasparotto Junior A, Bashir A. Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME- Induced Hypertensive Rats. Cardiovascular Therapeutics. 2023, 2023. |
| [20] |
Riaz R, Younis W, Uttra AM, Malik MN, Manzoor W, Qasim S, Hasan UH, Mushtaq MN, Kluck AJ, dos Reis Lívero FA, Junior AG. Anti-arthritic and anti-inflammatory activity of linalool against formaldehyde and complete Freund’s adjuvant induced arthritis in rats. Biochemical and Biophysical Research Communications. 2025 Feb 12:151462. |
| Co-author Publications |
| [21] |
Sadaf B, Mushtaq MN, Younis W, George B, Anjum I, Aleem A. Nerolidol attenuates cardiac hypertrophy and fibrosis in mice: Modulation of collagen type I, apoptotic and endothelial gene expression. Iranian Journal of Basic Medical Sciences. 2026 May 20. |
| [22] |
Asif H, Chohan TA, Irfan HM, Asim MH, Bukhari SN, Younis W, Althobaiti YS, Ullah A, Khan AQ, Hakami AY. Ex vivo, in vitro, and in silico approaches to unveil the mechanisms underlying vasorelaxation effect of Mentha Longifolia in porcine coronary artery. Biomedicine & Pharmacotherapy. 2022,1;153:113298. |
| [23] |
Batool A, Saleem M, Irfan HM, Younis W, Alotaibi NH, Alharbi KS, Bukhari SN, Locatelli M, Saleem H. Study on vascular mechanisms underlying the hypotensive effect of Sorghum halepense (L.) Pers. Pakistan Journal of Pharmaceutical Sciences. 2020, 3;33. |
| [24] |
Sharif A, Saleem M, Alotaibi NH, Alharbi KS, Bukhari SN, Irfan HM, Younis W. Blood pressure lowering effects of Ranunculus scleratus Linn. in normal and fructose induced hypertensive rats and estimation of underlying mechanisms. Pakistan Journal of Pharmaceutical Sciences. 2020, 3;33. |
| [25] |
Noor N, Alyami BA, Alqarni AO, Alqahtani YS, Mahnashi MH, Akram M, Qasim S, Younis W, Ali E, Shamim R. Appraisal of hypotensive effect of natural monoterpene: Bornyl acetate and in-silico molecular docking analysis. Pakistan Journal of Pharmaceutical Sciences. 2021, 2;34. |
| [26] |
Mushtaq MN, Akhtar MS, Alamgeer AT, Khan HU, Maheen S, Ahsan H, Naz H, Asif H, Younis W, Tabassum N. Evaluation of antihypertensive activity of Sonchus asper L. in rats. Acta Pol Pharm Drug Res. 2016, 1;73:425-31. |
| [27] |
Uttra AM, Khan KU, Khan IU, Saleem M, Ahsan H, Asif H, Sharif A, Younis W, Naz H. Evaluation of hepatoprotective potential of Euphorbia prostrata ait extract against chemically induced hepatotoxicity in albino mice. Acta Pol Pharm Drug Res. 2017, 5;74:1477-148 |
| [28] |
Ahsan H, Khan KU, Khan IU, Saleem M, Khadija HA, Sharif A, Younis W, Naz H. Evaluation of hepatoprotective activity of Melilotus officinalis L. against paracetamol and carbon tetrachloride induced hepatic injury in mice. . Acta Pol Pharm Drug Res. 2017, 3;74:903-9. |
| [29] |
Alamgeer, Younis W, Asif H, Sharif A, Riaz H, Bukhari IA, Assiri AM. Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence. Chinese medicine. 2018,13(1):1-29. |
| [30] |
Sharif A, Asif H, Younis W, Riaz H, Bukhari IA, Assiri AM. Indigenous medicinal plants of Pakistan used to treat skin diseases: a review. Chinese medicine. 2018, 13:1-26. |
| [31] |
Nasreen P, Uttra AM, Asif H, Younis W, Hasan UH, Irfan HM, Sharif A. Evaluation of anti-inflammatory and analgesic activities of aqueous methanolic extract of Ranunculus muricatus in albino mice. Pakistan Journal of Pharmaceutical Sciences. 2020,1;33(3). |
| [32] |
Afzal S, Younis W, Ahmad H, Ahmad T. Scientific Rationale for the Use of Peganum Harmala in Cardiovascular Diseases. Phytopharmacological Communications. 2021, 29;1(01):17-26. |
| [33] |
Haseeb A , Sarfraz A , Ihtisham H , Waqas Y , Rizwan H. (2016) Fabrication And Evaluation Of Fast Disintegrating Tablets Of Atorvastatin To Improve Dissolution Profile And Solubility. International Journal Of Biology Pharmacy And Allied Sciences (IJBPAS)., 5(2), 201-213, 2016. |
| [34] |
Bashir A, Mushtaq MN, Younis W, Anjum I. Fenchone a monoterpene: Toxicity and diuretic profiling in Rats. Frontiers in Pharmacology. 2023, 26;14:3. |
| [35] |
Zaib M, Malik MN, Shabbir R, Mushtaq MN, Younis W, Jahan S, Ahmed I, Kharl HA. Imine Derivatives of Benzoxazole Attenuate High-Fat Diet-Induced Hyperlipidemia by Modulation of Lipid-Regulating Genes. ACS omega. 2023, 17. |
| [36] |
Rafique F, Mushtaq MN, Ahmed H, Younis W. Evaluation and estimation of diuretic activity of the linalyl acetate in the rats. Brazilian Journal of Biology. 2023;83:e277354. |
| [37] |
Bashir A, Mushtaq MN, Anjum I, Younis W, Usman H, Anwar F, Dauelbait M, Bin Jardan YA, Bourhia M. Diuretic Potential of Fenchyl Acetate with Its Mechanism of Action: Toxicity Study. ACS omega. 2023 Nov 15;8(47):44880-92. |
| [38] |
Rafique F, Younis W, Mumtaz H, Jabbar A, Arshad E, Shahbaz Z, Khawar A. Neryl Acetate: A Natural Compound with Promising Therapeutic Benefits. Journal of Pharma and Biomedics. 2024 Dec 30;2(2):91-100. |
| [39] |
Uttra AM, Ahmad S, Ahmad T, Qasim S, Afzal HS, Younis W. The therapeutic potential of Ribes orientale in hypertension: Improving electrolyte balance, enhancing antioxidant activity, and modulating the muscarinic pathway. InAnnales Pharmaceutiques Françaises 2025 Mar 1 (Vol. 83, No. 2, pp. 389-400). Elsevier Masson. |
| [40] |
Hafiz Muhammad Bila Muhammad Atif , Muhammad Nasir Hayat Malik , Tariq G. Alsahli , Muhammad Ali , Waqas Younis, Khalid Saad Alharbi, Sami I. Alzare, Bader Alsuwayt, Tahir Maqbool, Irfan Anjum, Shah Jahan, Abdullah R. Alanzi, Gideon F. B. Solre. p-Cymene inhibits pro-fibrotic and inflammatory mediators to prevent hepatic dysfunction, Open Life Sciences: 2025: 20: 20221054. |
| [41] |
Anwar N, Malik MN, Atif M, Alanzi AR, Alharbi HA, Younis W, Abbas M, Solre GF. p‐Cymene Targets Multiple Oncogenic Pathways in Hepatocellular Carcinoma: Insights From Network Pharmacology and In Vitro Studies. Food Science & Nutrition. 2025 Oct;13(10):e71108. |